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In retinal ischemia, the rise in intracellular Ca 2+ levels determines the beginning of excitotoxic glutamate-related neuronal death [135] that occurs in RGCs of rats due to the activation of AMPA/kainite receptors during visual processing, which facilitates the influx of Ca 2+ through NMDA receptors [134]

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Moreover, PAT induce DNA damage and cell cycle arrest along with intrinsic pathway mediated apoptosis which may have dermal toxicological implications [172]